Research Papers
Mycobacterium tuberculosis Genotypes in patients developing pulmonary tuberculosis related acute respiratory distress syndrome
Authors:
Nawal Salahuddin ,
AGA KHAN UNIVERSITY, PK
About Nawal
Associate Professor, Section Of Pulmonary & Critical Care, Department of Medicine
Mahnaz Tanveer,
AGA KHAN UNIVERSITY, PK
About Mahnaz
Research assistant, Department of Microbiology
Nisar Rao,
AGA KHAN UNIVERSITY, PK
About Nisar
Lecturer,Section Of Pulmonary & Critical Care, Department of Medicine
Saeed Akram,
Aga Khan University, PK
About Saeed
Fellow, Section Of Pulmonary & Critical Care, Department of Medicine
Zahra Hasan,
AGA KHAN UNIVERSITY, PK
About Zahra
Associate Professor, Department of Microbiology
Rumina Hasan
Aga Khan University, PK
About Rumina
Professor, Department of Microbiology
Abstract
Background: Acute Respiratory Distress Syndrome is an uncommon but frequently fatal presentation of pulmonary TB. We attempted to identify whether a specific M. tuberculosis genotype occurs more commonly in patients who develop ARDS.
Methods: An observational study carried out at the Aga Khan University Hospital, Karachi, Pakistan enrolled all ARDS patients with tuberculosis. MTB isolates were spoligotyped for strain identification.
Results: 725 patients were admitted with pulmonary tuberculosis during the study period. Only 2.5% (18 patients) developed ARDS. Inpatient mortality rate was 58% (7 patients). Genotypes of M. tuberculosis isolates were predominantly CAS I (58.3%) and Unique strains (25%). Beijing and CAS subfamilies were less common; with each genotype identified in 8.3% patients respectively. All except one of the isolated strains were sensitive to usual first line anti-tubercular drugs.
Conclusion: Our results indicate that the CAS1 strains are the most common genotypic strains causing severe respiratory disease in patients with ARDS.
DOI: http://dx.doi.org/10.4038/sljcc.v2i1.2370
Sri Lanka Journal of Critical Care Vol.2(1) 2011 20-24
Background:
Acute
Respiratory
Distress
Syndrome
is
an
uncommon
but
frequently
fatal
presentation
of
pulmonary
TB.
We
attempted
to
identify
whether
a
specific
M.
tuberculosis
genotype
occurs
more
commonly
in
patients
who
develop
ARDS.
Methods:
An
observational
study
carried
out
at
the
Aga
Khan
University
Hospital,
Karachi,
Pakistan
enrolled
all
ARDS
patients
with
tuberculosis.
MTB
isolates
were
spoligotyped
for
strain
identification.
Results:
725
patients
were
admitted
with
pulmonary
tuberculosis
during
the
study
period.
Only
2.5%
(18
patients)
developed
ARDS.
Inpatient
mortality
rate
was
58%
(7
patients).
Genotypes
of
M.
tuberculosis
isolates
were
predominantly
CAS
I
(58.3%)
and
Unique
strains
(25%).
Beijing
and
CAS
subfamilies
were
less
common;
with
each
genotype
identified
in
8.3%
patients
respectively.
All
except
one
of
the
isolated
strains
were
sensitive
to
usual
first
line
anti-tubercular
drugs.
Conclusion:
Our
results
indicate
that
the
CAS1
strains
are
the
most
common
genotypic
strains
causing
severe
respiratory
disease
in
patients
with
ARDS.
How to Cite:
Salahuddin, N. et al., (2011). Mycobacterium tuberculosis Genotypes in patients developing pulmonary tuberculosis related acute respiratory distress syndrome. Sri Lanka Journal of Critical Care. 2(1), pp.20–24. DOI: http://doi.org/10.4038/sljcc.v2i1.2370
Published on 27 Dec 2011.
Peer Reviewed
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